Large left atrial myxoma with synchronous laryngeal squamous cell carcinoma: A case report.

Background: Cardiac myxoma is a benign neoplasm and one of the most common types of primary cardiac tumors. Synchronous cardiac myxoma and other malignancies are extremely rare, and only limited cases have been reported.

Case Summary: We describe a young patient with newly diagnosed locally advanced laryngeal cancer, with a synchronous cardiac tumor detected on staging scans.

Occlusion of TCR binding to HLA-A*11:01 by a non-pathogenic human alloantibody.

Over the last decades, organ transplantation has made rapid progress as a curative therapy for organ failure. However, the adaptive immune system-alloreactive T cells and antibodies targeting human leukocyte antigens (HLA)-is the leading cause of graft rejection. The presence of anti-donor HLA antibodies is considered a risk factor that disqualifies a particular donor-recipient pair.

Examining psychological distress among youth in Singapore: Insights from the National Youth Mental Health Study.

Youth is a period of transition associated with immense biological, physical, and social changes, which increases the vulnerability to mental illnesses. The study aimed to establish the prevalence of severe and extremely severe levels of depression and anxiety symptoms among the youths in Singapore and identify the psycho-social factors associated with them. The National Youth Mental Health Study was a cross-sectional epidemiological study of Singapore Residents aged 15-35 years.

Severity of Chronic Kidney Disease as Assessed by the Kidney Failure Risk Equation Is Associated With Incident Acute Ischemic Stroke.

Aim: Stroke is a leading cause of death and disability, with substantial healthcare implications. Chronic kidney disease (CKD) is similarly impactful, and emerging evidence links CKD to a higher stroke risk. Despite this, stroke risk assessment in CKD patients remains limited.

Mechanistic insight into the induction of liver tissue-resident memory CD8 T cells by glycolipid-peptide vaccination.

We recently demonstrated that vaccines comprising antigenic peptides conjugated to a glycolipid agonist, termed glycolipid-peptide (GLP) vaccines, efficiently generate substantial numbers of long-lived CD8 liver-resident memory T (Trm) cells that are crucial for protection against malaria liver-stage infection. To understand the underlying mechanism, we examined the prerequisites for priming, differentiation, and secondary boosting of liver Trm cells using these GLP vaccines. Our study revealed that generation of long-lived liver Trm cells relies on CD8 T cell priming by type 1 conventional dendritic (cDC1) cells, followed by post-priming exposure to a combination of vaccine-derived inflammatory and antigenic signals.