Publications by authors named "Y J Summers"
Objectives: This study aimed to compare the overall survival (OS) of patients with advanced EGFR-mutant NSCLC treated with first-line osimertinib versus earlier-generation EGFR tyrosine kinase inhibitors (TKIs) in a real-world setting. Secondary endpoint included OS in patients with uncommon EGFR mutations. Exploratory aim focused on the impact of TKIs sequencing strategies.
View Article and Find Full Text PDFBackground: Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone.
Methods: MARS 2 was a phase 3, national, multicentre, open-label, parallel two-group, pragmatic, superiority randomised controlled trial conducted in the UK.
Purpose: Electronic patient-reported outcome measures (ePROMs) are digitalized health questionnaires used to gauge patients' subjective experience of health and disease. They are becoming prevalent in cancer care and have been linked to a host of benefits including improved survival. MyChristie-MyHealth is the ePROM established at the Christie NHS Foundation Trust in 2019.
View Article and Find Full Text PDFArticle Synopsis
- The UK National Screening Committee recommended low-dose CT lung cancer screening in September 2022, following successful trials that showed a decrease in lung cancer deaths.
- While these trials demonstrate clinical effectiveness, further efforts are needed to ensure the screening can be delivered on a national level.
- A group of experts, including clinicians and scientists, met to discuss implementation priorities, and their findings aim to guide the expansion of lung cancer screening programs in the UK and serve as a reference for other countries.