Insights into , a Large-sized, Phylogenetically Unique Type Ia Methanotroph with Biotechnological Potential.

The cultivation of microorganisms is important as it provides us an opportunity to explore the characteristics that can be used for a variety of applications. Methanotrophs oxidize methane and are one of the most challenging organisms to culture. In 2018, we cultured one of the largest methanotrophs within the gammaproteobacterial group (Type Ia), a novel genus and species, , with large peculiar, elongated oval (cucumber-shaped) cells (~ 3-6 µm length × 1.

Relationship between smoking and pulmonary tuberculosis based on positive sputum smears.

Introduction: Smoking and tuberculosis are the two major, global health problems. Not only active smokers but also passive smokers are at risk of becoming infected with tuberculosis. Through many mechanisms, smoking decreases immunity and predisposes to numerous infections.

Functional Outcome of Intertrochanteric Fractures of the Femur Treated With Standard Surgical Modalities.

Introduction: Among the most prevalent injuries among the elderly with trivial trauma are trochanteric fractures. Osteoporosis and female sex are additional risk factors. The patient's age, the fracture, their overall health, the amount of time between the fracture and treatment, the effectiveness of the treatment, any concurrent medical care, and the stability of the fixation all affect how well the patient responds to treatment.

A multicomponent nanosystem for capturing circulating tumor cells from cancer patients with PD-L1 as an immunotherapy oncotarget.

Capturing circulating tumor cells (CTCs) from the peripheral blood of cancer patients, where they are disseminated among billions of other blood cells, is one of the most daunting challenge. We report OncoDiscover®, a multicomponent nano-system consisting of iron oxide (FeO) nanoparticles (NPs), polyamidoamine generation 4 dendrimers (PAMAM-G4-NH), graphene oxide (GO) sheets and an anti-epithelial cell adhesion molecule (anti-EpCAM) antibody (Fe-GSH-PAMAM-GO-EpCAM) for the selective and precise capture of CTCs. We further evaluated this system for therapeutically important oncotargets, exemplifying overexpression of the programmed death ligand 1 (PD-L1) as a functional assay on CTCs in cancer patients.