Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.

Sleep is crucial for sustaining normal physiological functions, and sleep deprivation has been associated with increased pain sensitivity. The histone deacetylases (HDACs) are known to significantly regulate in regulating neuropathic pain, but their involvement in nociceptive hypersensitivity during sleep deprivation is still not fully understood. Utilizing a modified multi-platform water environment technique to establish a sleep deprivation model.

Epidemiological Features of Sinonasal Adenocarcinoma and Prognostic Nomogram: A Study Based on the SEER Database.

Objective: Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).

Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival.

Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis.

The aggregation state of nano-TiO in the environment is altered under marine heatwaves (MHWs), thus affecting its bioavailability and toxicity to the marine organisms. Here, we investigated the toxic mechanisms and effects of nano-TiO on gut-hepatopancreas axis health of Mytilus coruscus exposed to 25 and 250 μg/L of nano-TiO under laboratory-simulated MHW. Compared with the control conditions or post-MHW cooling phase, prolonged MHW exposure significantly inhibited digestive function, decreased immune-related enzymes activities, and caused neurotoxicity in the mussels.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.