Publications by authors named "Y J Jong"
Background And Objectives: Safety and efficacy of IV onasemnogene abeparvovec has been demonstrated for patients with spinal muscular atrophy (SMA) weighing <8.5 kg. SMART was the first clinical trial to evaluate onasemnogene abeparvovec for participants weighing 8.
View Article and Find Full Text PDFBackground: Surgical site infections (SSIs) lead to increased mortality and morbidity, as well as increased healthcare costs. Multiple models for the prediction of this serious surgical complication have been developed, with an increasing use of machine learning (ML) tools.
Objective: The aim of this systematic review was to assess the performance as well as the methodological quality of validated ML models for the prediction of SSIs.
The most common mutation in southern Chinese individuals with late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD; a fatty acid metabolism disorder) is c.250G > A (p.Ala84Thr) in the electron transfer flavoprotein dehydrogenase gene (ETFDH).
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed new 3D cell culture models using HBV-infected primary human hepatocytes (PHH) to improve on traditional methods that have short lifespans and low infection rates.
- The new models, which include de novo HBV-infected mouse-passaged PHH, showed sustained infection and human albumin levels for up to 75 days, significantly extending their usability.
- The team used these 3D models for drug testing and successfully validated an HBV capsid assembly modulator, highlighting the models' potential for advancing HBV research and drug development.