Synthesis of Polycyclic Heteroarenes via Rh(III)-Catalyzed Twofold C-H Activation of 3-Aryl-2-benzo[][1,4]oxazines and Annulation with α-Diazo-β-ketoesters.

An efficient Rh(III)-catalyzed annulation between 3-aryl-2-benzo[][1,4]oxazines and α-diazo-β-ketoesters was developed, affording a series of polycyclic heteroarenes in moderate to excellent yields with good functional group compatibility. The procedure featured high efficiency, redox neutrality, twofold -C-H activation, and dual [4 + 2] annulation. Moreover, several important intermediates and products have been isolated as powerful evidence for the proposed reaction mechanism.

Single-pixel complex-field imaging through scattering media.

Much research in optics was conducted to retrieve phase of the light field, e.g., via a reference wave (such as holography) or single-path optical diffraction.

Isolation, characterization and virulence assessment of Type 1d CP bovine viral diarrhea virus originating from Inner Mongolia, China.

In recent years, bovine viral diarrhea virus (BVDV) has been associated with increased respiratory and gastrointestinal diseases in cattle. Comprehensive monitoring and investigations into the virus's pathological features are crucial for developing effective prevention strategies. This study investigated BVDV prevalence and pathogenicity in farms undergoing elimination protocols, with a focus on characterizing a novel Cytopathic Bovine Viral Diarrhea Virus (CP-type BVDV) strain (HH839) isolated from a symptomatic calf in Hohhot, Inner Mongolia.

Bioeliminable Pt@BiSe-RGD Nanoassembly for Enhancing Photoacoustic Imaging-Guided Tumor Immuno-Radiotherapy by Inducing Apoptosis via the Areg Pathway.

Nanoradiosensitizers containing high Z-group elements have been reported widely as potential candidates for radiotherapy. However, the specific regulatory mechanism is unclear, and biodegradability needs to be addressed urgently. We synthesized a silk sericin-containing nano assembly, Pt@BiSe-RGD (PBR).

design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers.

Small molecules that can reduce the neurotoxic beta-amyloid (Aβ) aggregates in the brain provide a potential treatment for Alzheimer disease (AD). Most screening methods for small-molecule hits focus on the overall Aβ aggregations without a specific target, such as the very first association step (i.e.