Publications by authors named "Y Iwatani"

Objective: Although sleep habits are associated with the development of toddlers, factors affecting social development and brain function remain unclear. We aimed to elucidate the relationship between sleep habits and social development as well as brain coherence in toddlers.

Methods: We used the data set at 1.

View Article and Find Full Text PDF

Abemaciclib (ABM) is recommended for adjuvant endocrine therapy in hormone receptor-positive, human epidermal growth factor receptor type 2-negative early breast cancer (EBC) patients at high risk of recurrence. Here, we present a case of radiation hepatitis challenging to differentiate from drug-induced liver injury during ABM treatment. The patient, a woman in her 40 s, underwent right mastectomy, axillary dissection, and postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy for EBC.

View Article and Find Full Text PDF
Article Synopsis
  • Monozygotic (MZ) twins develop from a single fertilized egg, making them genetically identical, but can acquire differences through postzygotic somatic mutations (PZMs) following separation.
  • In a study involving 30 healthy MZ twin pairs, whole-genome sequencing (WGS) revealed over 99% genetic concordance and highlighted the accumulation of PZMs primarily in non-coding regions, which might affect gene expression.
  • The research also discovered a missense mutation in the ANKRD35 gene among the PZMs and identified an age-related mutational pattern, deepening the understanding of genetic variation in MZ twins.
View Article and Find Full Text PDF

Background And Objective: Primary angiosarcoma of the breast (PBA) is an extremely rare and heterogeneous disease. PBA is difficult to diagnose and has a poor prognosis. In order to better understand the disease and provide evidence-based treatment for PBA patients, a review of the published literature in the English language was conducted.

View Article and Find Full Text PDF

The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined.

View Article and Find Full Text PDF