Publications by authors named "Y Ikeuchi"
Advanced computational models and simulations to unravel the complexities of brain function have known a growing interest in recent years in the field of neurosciences, driven by significant technological progress in computing platforms. Multicompartment models, which capture the detailed morphological and functional properties of neural circuits, represent a significant advancement in this area providing more biological coherence than single compartment modeling. These models serve as a cornerstone for exploring the neural basis of sensory processing, learning paradigms, adaptive behaviors, and neurological disorders.
View Article and Find Full Text PDFObjective: We investigated whether air in the cisterns or ventricles on postoperative computed tomography (CT) (reflecting the opening of the cerebrospinal fluid spaces during surgery) is a predictor of classical or nodular leptomeningeal disease (LMD) after resection of brain metastases.
Methods: We retrospectively analyzed 73 patients who underwent gross total resection of brain metastases between 2012 and 2020. Patients with air in the cisterns or ventricles on postoperative day 1 CT were categorized into the air-positive group, whereas those without air in the cisterns or ventricles on postoperative day 1 CT were categorized into the air-negative group.
Background/aim: Radiotherapy (RT) for advanced oropharyngeal cancer (OPC) is effective, especially when combined with chemotherapy (CRT). However, its success can vary depending on factors, such as tumor stage, HPV infection (p16 status), and the patient's nutritional and immune status. This study examined the controlling nutritional status (CONUT) score and tumor immunity as predictive factors for treatment outcomes in OPC, aiming to develop a personalized risk score.
View Article and Find Full Text PDFArticle Synopsis
- Photodynamic therapy (PDT) using talaporfin sodium is evaluated for its effectiveness in treating IDH-wildtype glioblastoma after surgical removal, with a focus on clinical outcomes and prognosis.
- In a study of patients from Kobe University Hospital, PDT resulted in significantly lower local recurrence rates and longer progression-free and overall survival times compared to patients not receiving PDT.
- Although PDT improved local control, it was associated with higher distant recurrence rates and some adverse events, highlighting the complexities of treatment outcomes.
Article Synopsis
- Scientists looked at how the environment around tumors in the brain and certain substances in the fluid around the brain can help predict if patients with a type of brain cancer called glioblastoma will have seizures before surgery.
- They studied 47 patients and found that a specific substance called sCD163 was lower in patients who had seizures compared to those who didn’t.
- The results suggest that measuring sCD163 in the fluid around the brain could help doctors anticipate seizures in these patients.