Publications by authors named "Y Ichiki"
Article Synopsis
- A study investigated the effects of short-term use of antihistamines alongside immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer to see if it improved treatment efficacy and reduced immune-related side effects.
- The research analyzed 211 patient records, dividing them into two groups: 109 patients who received H1 antihistamines during ICI treatment and 102 who did not.
- Results showed significantly better median progression-free survival (12.7 months vs. 4.3 months) and overall survival (32.8 months vs. 18.1 months) in the experimental group, suggesting that H1 antihistamines may be beneficial as a complementary treatment.
Article Synopsis
- Marfan syndrome is a genetic condition that weakens connective tissue, leading to various health complications.
- A 16-year-old boy with Marfan syndrome was treated for recurrent pneumothoraxes but faced unexpected tracheal stenosis during surgery, causing significant breathing issues.
- The case highlights the importance of identifying potential airway abnormalities in Marfan syndrome patients, as general anesthesia can exacerbate these conditions; careful collaboration between surgeons and anesthesiologists is crucial for patient safety.
Article Synopsis
- Neoadjuvant chemoimmunotherapy (NACI) is the recommended treatment for patients with operable non-small cell lung cancer (NSCLC), but finding a reliable predictor for achieving a pathological complete response (pCR) remains a challenge.* -
- A review of 50 relevant studies published between 2018 and 2022 highlighted various potential predictors for pCR, including imaging techniques like F-FDG-PET, tumor microenvironment factors, and clinical markers such as neutrophil-to-lymphocyte ratio (NLR) and smoking history.* -
- Notably, a full metabolic response on PET scans showed a 71.4% positive predictive value for pCR, while specific patterns in tumor
Solitary pulmonary papillomas (SPPs) are rare lung neoplasms. Histologically, SPP is classified into three subtypes, and mixed squamous and glandular papilloma (MP) is the rarest subtype. Although SPPs are considered benign tumors, there have been several reports on the synchronous malignant transformation in SPPs.
View Article and Find Full Text PDFBackground: To date, the role of programmed death ligand-1 (PD-L1) messenger RNA (mRNA) derived from tumor-educated platelets (TEPs) has not been well investigated in patients with advanced non-small cell lung cancer (NSCLC). A few reports have examined whether mRNA in TEPs can predict the clinical responses of patients with advanced NSCLC following immunotherapy. This study aimed to identify novel biomarkers to improve the clinical benefits and outcomes of NSCLC patients.
View Article and Find Full Text PDF