Publications by authors named "Y IDA"
Background/objectives: The objective of the present study was to examine the unidentified effects that RHO-associated coiled-coil-containing protein kinase 1 and 2 antagonists exert on the transforming growth factor beta2-induced epithelial-mesenchymal transition of the human corneal stroma.
Methods: In the presence or absence of pan-RHO-associated coiled-coil-containing protein kinase inhibitors, ripasudil or Y27632 and RHO-associated coiled-coil-containing protein kinase 2 inhibitor, KD025, we analyzed the following: (1) planar proliferation caused by trans-endothelial electrical resistance and the cellular metabolic characteristics of the two-dimensional cultures of human corneal stroma fibroblasts; (2) the physical properties of a three-dimensional human corneal stroma fibroblasts spheroid; and (3) the gene expressions and their regulators in the extracellular matrix, along with the tissue inhibitors of metalloproteinases and matrix metalloproteinases and the endoplasmic reticulum stress-related factors of the two-dimensional and three-dimensional cultures in human corneal stroma fibroblasts.
Results: Exposure to 5 nM of the transforming growth factor beta2 markedly increased the trans-endothelial electrical resistance values as well as the metabolic function in two-dimensional cultures of human corneal stroma fibroblasts.
This study evaluated the effects of HEMA and 10-MDP in the bonding agent in a 2-step self-etch adhesive system, Clearfil SE Bond 2, on water sorption (W) and elastic modulus (E) of the polymerized bonding agent. The microtensile bond strength (µTBS) to dentin was also evaluated initially and after 10,000 thermal cycles (TC10,000). Four bonding agents were tested: the original, H-free (excluding HEMA), M-free (excluding 10-MDP), and HM-free (excluding HEMA and 10-MDP).
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- Telemedicine in Japan has grown due to COVID-19 deregulation, but its current use is mainly by general practitioners and is still unclear.
- This study examines telemedicine's role in sublingual immunotherapy (SLIT) for allergies, comparing patients who used a mix of telemedicine and in-person visits to those who only had in-person visits.
- Results showed no significant differences in dropout rates, side effects, or treatment effectiveness, although telemedicine patients had higher copayment costs; further research is needed to clarify telemedicine's status in Japanese healthcare.
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- Oculoplastic surgery faces unique challenges when reconstructing large defects from malignant lower lid tumors, and this case study focuses on the effective use of a step ladder V-Y advancement flap for reconstruction.
- Five patients underwent tumor removals and reconstructions from November 2018 to March 2023, successfully using this flap technique without any complications.
- The step ladder V-Y advancement flap is advantageous due to its minimal impact on healthy skin, small dissection area, and overall efficiency, making it a preferred choice for aesthetic reconstruction after tumor excision.
Introduction: Patients with liver cirrhosis develop thrombocytopenia and an increased risk of bleeding events after invasive procedures. Lusutrombopag, a thrombopoietin receptor agonist, can increase the platelet count. This study assessed whether lusutrombopag reduces the risk of hemoperitoneum following percutaneous radiofrequency ablation for hepatocellular carcinoma, compared with platelet transfusion.
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