Publications by authors named "Y I Nabeshima"
Transthyretin (TTR), a plasma protein, undergoes transformation into amyloid fibers, leading to ATTRv amyloidosis, a disease characterized by organ deposition of TTR amyloid fibrils and subsequent organ failure. Developing compounds that bind and kinetically stabilize TTR is a crucial strategy in the treatment of ATTRv amyloidosis. In this study, we narrowed 651 pesticide-related compounds down to 14 possible TTR binders through in silico screening; subsequent in vitro analysis revealed that 7 of them exhibited amyloid fibril formation inhibition activity.
View Article and Find Full Text PDFRationale: Anti-mitochondrial antibodies (AMA) M2-positive myositis can lead to severe respiratory failure. Traditional immunotherapies sometimes fail to address respiratory failure. Herein, this CARE-compliant case report described a patient with AMA-M2-positive myositis who recovered from ventilation with tracheostomy owing to immunotherapy-resistant respiratory failure to spontaneous breathing after modified lung volume recruitment (mLVR) therapy.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how well deep-learning (DL) models can analyze electrocardiograms (ECGs) to predict changes in the left ventricle related to significant aortic regurgitation (AR), which has been challenging to identify in the past.
- - Researchers collected data from 573 patients and used a ResNet-based model to correlate ECG readings with various left ventricular parameters, achieving promising scores in distinguishing levels of left ventricular dysfunction.
- - The findings suggest that using DL models on ECGs could improve the detection of left ventricular issues and potentially reduce the need for additional echocardiography, especially in situations where access to such tests is limited.
Article Synopsis
- The study examines the reliability of the relative apical sparing (RAPS) pattern in diagnosing cardiac amyloidosis and its prognostic significance, highlighting concerns over its accuracy.
- A systematic review of 37 studies found that RAPS has a pooled sensitivity of 61% and specificity of 83%, but diagnostic accuracy varied significantly among different analytical software.
- While RAPS showed some association with outcomes in cardiac amyloidosis, its prognostic value diminished when further analyzed, suggesting it is not a strong predictor of patient outcomes.
Article Synopsis
- - This study aimed to evaluate how right ventricular ejection fraction (RVEF) relates to adverse outcomes in various cardiovascular diseases (CVD) using a Bayesian model-averaged meta-analysis approach.
- - Analysis of 108 articles with over 21,000 patients showed that while RVEF is generally associated with worse outcomes, strong evidence was mainly found for just four specific CVDs: hypertrophic cardiomyopathy, dilated cardiomyopathy, pulmonary hypertension, and aortic stenosis.
- - The study suggests that more data could improve our understanding of RVEF's impact on other types of CVD, as current evidence for those is weaker.