Morphological and functional evaluation of the effect of novel pyrimidine derivatives on regeneration of the sciatic nerve in rats.

Two novel pyrimidine derivatives, RG2 and RG6, were studied using a rat's model of peripheral nerve injury. Toe-spreading reflex and skin sensitivity to pinch in the foot were monitored to follow recovery of motor and sensory functions in the treated animals. The remyelation rate in the distal segment of the damaged nerve was also studied using morphological analysis of cross-sections of the nerve stained with methylene blue.

Electrochemical investigation of palladium complexes with organic sulphides and their use in extraction differential pulse polarography.

Dialkyl-, amino-, keto- and ketoaminosulphide complexes of palladium(II) are shown to undergo one- or two-step reduction in a mixed acetonitrile-toluene solvent containing Bu(4)NClO(4) at 0.1 M concentration. The half-wave potentials of the complexes show a certain dependence on the ligand structure, a positive shift of the potentials being caused by an increase in the pi-acceptor ability of the ligands.