Association between triglyceride to high-density lipoprotein cholesterol ratio and microalbuminuria in the Chinese population.

The evidence for the association between the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-c) ratio and the risk of developing microalbuminuria is still limited in the Chinese population. Therefore, our research will endeavor to explore the relationship between the two. The cross-sectional survey enrolled 32,877 general population from eight regional centers in China.

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.

Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood.

The characterization of outer membrane vesicles (OMVs) and their role in mediating antibiotic-resistance gene transfer through natural transformation in Riemerella anatipestifer.

Riemerella anatipestifer (R. anatipestifer, RA) is the etiological agent of duck serositis, an acute multisystemic disease in ducks that is globally distributed and causes serious economic losses in the duck industry. Despite exhibiting multidrug resistance, the transmission mechanism of its antibiotic resistance genes (ARGs) remains incompletely identified.

Evaluation of metabolite stability in dried blood spot stored at different temperatures and times.

Dried blood spot (DBS) sampling offers significant advantages over conventional blood collection methods, such as reduced sample volume, minimal invasiveness, suitability for home-based sampling, and ease of transport. However, understanding the effects of variable storage temperatures and times on metabolite stability is crucial due to varying intervals and delivery conditions between sample collection and metabolomics analysis. To minimize biological variances, all samples were collected from the same individual simultaneously and stored at three different temperatures (4 °C, 25 °C, and 40 °C) for diverse time points (3, 7, 14, and 21 days).

Design and mechanical properties analysis of drill pipe's joint thread with unequal taper under complex loads.

The design of drill pipe joint thread with unequal taper is proposed to investigate the fracture failure of the API NC38 used in the drill pipe joint of the SU36-8-4H2 well. The effect of changes in thread taper on the stress distribution and mechanical properties of drill pipe joints is analyzed and compared with the API standard thread to determine the optimal thread structure with unequal taper. The results reveal highly concentrated stress at the last engaged thread root of API NC38 single-shoulder thread (SUT) may cause early yield failure of the joint threads.