Publications by authors named "Y I Gurfinkel"

In this study, the parameters of blood microcirculation and microrheology were measured using the methods of laser aggregometry and optical tweezers in vitro, as well as the method of digital capillaroscopy in vivo. It was shown that in patients suffering from type 2 diabetes mellitus, an increase in the number of RBC aggregates passing through the narrow capillaries leads to a significant decrease in the velocity of the capillary blood flow, which can be explained by the increased viscosity of the whole blood and decreased deformability of RBCs. Also, for the group of patients, a statistically significant increase in the rate of RBC aggregation and the hydrodynamic strength of aggregates, RBC aggregation and disaggregation forces were observed compared to the control group.

View Article and Find Full Text PDF

Optical clearing agents (OCAs) are substances that temporarily modify tissue's optical properties, enabling better imaging and light penetration. This study aimed to assess the impact of OCAs on the nail bed and blood using in vivo and in vitro optical methods. In the in vivo part, OCAs were applied to the nail bed, and optical coherence tomography and optical digital capillaroscopy were used to evaluate their effects on optical clearing and capillary blood flow, respectively.

View Article and Find Full Text PDF

Coronary heart disease (CHD) and atrial fibrillation (AF) pose significant health risks and require accurate diagnostic tools to assess the severity and progression of the diseases. Traditional diagnostic methods have limitations in providing detailed information about blood flow characteristics, particularly in the microcirculation. This study's objective was to examine and compare the microcirculation in both healthy volunteers and patient groups with CHD and AF.

View Article and Find Full Text PDF
Article Synopsis
  • Mutations in the TBK1 gene are linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), accounting for about 3-4% of cases with over 100 distinct mutations identified.
  • Missense mutations' disease mechanisms remain unclear, but they may affect TBK1's role in neuroinflammation and autophagy regulation.
  • The review summarizes the functional effects of TBK1 missense mutations and provides new modeling data predicting their structural impacts.
View Article and Find Full Text PDF

Purpose: To evaluate associations of refractive error and heterophoria with best-corrected visual acuity and stereoacuity in a population of healthy young adults.

Methods: Data extracted from the Israeli Defense Forces Air Force candidates database was analyzed retrospectively. Myopia and hyperopia were defined as spherical equivalent of ≤ -0.

View Article and Find Full Text PDF