The advantages and limitations of impedance aggregometry in detection of heparin-induced thrombocytopenia.

Background: Heparin-induced thrombocytopenia (HIT) represents a serious complication of heparin treatment. IgG antibodies binding platelet factor 4 (PF4) and heparin trigger the clinical manifestations of HIT. However, only a portion of the antibodies have the ability to activate platelets, and these can be identified by a platelet aggregation test (functional testing).

[Dabigatran etexilate in clinical practice for prevention of thromboembolic events in patients with atrial fibrillation].

Dabigatrane is the first new generation antiacoagulant that at a dose of 150 mg twice daily was, in the RE-LY study, more effective in cerebrovascular event and systemic embolisation prevention than well-controlled warfarin and had comparable or better safety profile than well-controlled warfarin. The 110 mg twice daily dose showed comparable efficacy and superior safety against warfarin. Crucial and unique among modern anticoagulants is its ability to significantly reduce ischemic as well as hemorrhagic CVEs at a dose of 150 mg twice daily.

[Basic anthropometric characteristics and their relationship with the metabolism of saccharides in women with PCOS].

Aim Of Study: To determine basic anthropometric characteristics and their relationship with the metabolism of saccharides in women with PCOS in the Olomouc region.

Type Of Study: Retrospective study of the results of 72 women with PCOS examined in the endocrinology clinic.

Material And Method: The study entailed the processing of data gained on the basis of examination of women sent to endocrinology clinic for examination in the years 2008-2010, who corresponded to the diagnostic criteria for PCOS according to the Rotterdam consensus.

[Infective endocarditis--crucial early diagnosis].

A 64-year old female patient with polymorbidity, including diabetes, was admitted to our clinic with a suspicion of silent myocardial infarction. However, no acute coronary lesion was subsequently confirmed. Transthoracal echocardiography performed just after the admission suggested infective endocarditis.

[Idiopathic hypoparathyroidism with celiac disease--diagnostic and therapeutic problem].

A middle-aged woman developed gradually diseases where most probably the common denominator is an autoimmune process. The authors describe the clinical condition persisting for seven years, where hypoparathyroidism was associated with coeliac disease which did not respond to dietary measures. Malabsorption was manifested by a selective block for calcium absorption from the gut.