Publications by authors named "Y Hosoya"
Article Synopsis
- Aging populations are experiencing higher rates of acute cardiovascular issues, with Impella being a costly yet effective support device that can lead to complications.
- In a study of 5,718 patients with cardiogenic shock, older patients (75 years and above) showed a significantly higher 30-day mortality rate compared to younger patients (38.9% vs. 32.5%) despite similar rates of Impella-related complications.
- Results indicate that older patients with various health indicators such as body mass index and existing conditions have distinct outcomes, suggesting the need for careful patient selection and longer follow-up in this demographic when using Impella.
Article Synopsis
- - This study investigates a new method for treating peritoneal metastasis (PM) by using AAV vectors to deliver a tumor-suppressing microRNA, miR-29b, to cells in the peritoneum, which is the lining of the abdominal cavity.
- - The research shows that AAV-DJ serotype effectively boosts miR-29b levels in peritoneal mesothelial cells, leading to reduced tumor cell attachment and decreased fibrosis, especially after a single intraperitoneal injection.
- - Furthermore, the combination of miR-29b delivery with traditional chemotherapy, like paclitaxel, improves treatment outcomes by inhibiting the growth of established PM from gastric and pancreatic cancers.
The prognosis of patients with osteosarcoma who experience recurrence or progression (R/P) is extremely poor, and more effective and less toxic therapies are needed. In the current study, the clinical data of osteosarcoma patients who experienced R/P were retrospectively analyzed to verify the reliability of O-6-methylguanine-DNA methyltransferase (MGMT) protein expression or MGMT promoter methylation for predicting the response to off-label temozolomide (TMZ)-containing chemotherapy. Of the 30 evaluable patients, 9 (30%) showed no/low MGMT protein expression, whereas all 16 evaluable patients had unmethylated MGMT promoter irrespective of MGMT protein expression levels.
View Article and Find Full Text PDFBackground/aim: A few case reports of central nervous system (CNS) symptoms caused by amantadine intoxication have been published, detailing various types of symptoms and differing times to onset. We encountered a patient who developed CNS symptoms with amantadine. This prompted us to investigate the types, time to onset, and outcome of CNS adverse reactions to amantadine by analyzing data from a pharmacovigilance database.
View Article and Find Full Text PDFBackground: Osteopenia reflects frailty and has been shown to be associated with outcomes in cancer patients. This study was undertaken to examine whether osteopenia is an independent prognostic factor in patients with esophageal cancer after resection.
Methods: A total of 214 patients who underwent surgery for esophageal cancer were analyzed retrospectively.