Publications by authors named "Y Horie"
Left atrial appendage closure is widely performed in cardiac surgery to prevent intracardiac thrombus in patients with atrial fibrillation. Herein, we report the surgical case of an 80-year-old man whose left atrial appendage became aneurysmic long after undergoing suture exclusion. At the age of 67, he underwent mitral valve annuloplasty and left atrial appendage suture exclusion for mitral regurgitation and chronic atrial fibrillation at our institution.
View Article and Find Full Text PDFZinc oxide nanoparticles (ZnO NPs) are widely used in manufacturing cosmetic and pharmaceutical products. Although previous studies have reported their toxic effects on fish, the underlying mechanisms behind their toxic effects are yet to be identified. This study evaluated the impact of ZnO NPs on marine medaka's survival, heart rates (Oryzias melastigma), and the expression of genes linked to neurotoxicity and cardiovascular toxicity.
View Article and Find Full Text PDFPurpose: Opioid-induced constipation is the most frequent and non-self-limiting adverse effect of opioid analgesia, reducing adherence and interfering with pain relief. This clinical trial aimed to clarify the preventive effect of naldemedine versus placebo for constipation in patients with cancer starting regularly dosed strong opioids therapy.
Methods: This multicenter, double-blinded, randomized, placebo-controlled, confirmatory trial was conducted between July 2021 and May 2023 at four academic hospitals in Japan (Japan Registry of Clinical Trials identifier: jRCTs031200397).
Article Synopsis
- This study analyzes real-world data from a comprehensive genomic profiling (CGP) of 1,364 patients with advanced small intestine cancer, focusing on identifying clinically relevant genetic alterations across different patient subgroups based on age and molecular characteristics.
- Key findings reveal that patients under 40 have a significantly lower rate of certain mutations compared to older patients, and 22.3% of the cohort had mutations that could be targeted by existing therapies.
- The results contribute to a better understanding of the genetic landscape of small intestine cancer, which may help guide future treatment strategies.
Microplastic abundance in the semi-enclosed Osaka Bay, Japan.
Environ Sci Pollut Res Int
August 2024
Article Synopsis
- Researchers identified and categorized anthropogenic particles in Osaka Bay using microscopy and spectroscopy, finding a total of 565.1 particles.
- Only 22.4% of these were plastic, with seasonal variations in microplastic abundance (8.9 to 22.8 particles/L from May to July).
- The main types of microplastics detected were fragmented fibers and included polymers like polypropylene, polyester, and polyethylene, with higher concentrations found offshore, likely due to local river runoff and marine activities.