Publications by authors named "Y Hoki"
Article Synopsis
- Genomic anomalies pose significant challenges for the safe use of induced pluripotent stem cells (iPSCs), and their origins and developmental processes are not fully understood.
- Whole genome sequencing (WGS) analysis reveals that the mutations in iPSCs are mainly new occurrences and highlights that regions like CpG sequences and retrotransposons, especially the AluY subfamily, are particularly mutation-prone.
- The study suggests that both the deamination of cytosine and the demethylation of methylated cytosine contribute to mutations during iPSC creation, indicating that these factors influence genome reprogramming.
This article addresses the practical aspect of medieval Arabic medicine by examining ophthalmological fragments of the Cairo Genizah, written between the tenth and thirteenth centuries. This article deals with two issues: (1) the logic behind the actual preparation of compound medicines and (2) the logic behind the entire treatment process. The first issue is examined by investigating recipes of eye medicines for leucoma (bayāḍ) recorded in genizah notebooks.
View Article and Find Full Text PDFWe here demonstrate that microsatellite (MS) alterations are elevated in both mouse and human induced pluripotent stem cells (iPSCs), but importantly we have now identified a type of human iPSC in which these alterations are considerably reduced. We aimed in our present analyses to profile the InDels in iPSC/ntESC genomes, especially in MS regions. To detect somatic de novo mutations in particular, we generated 13 independent reprogramed stem cell lines (11 iPSC and 2 ntESC lines) from an identical parent somatic cell fraction of a C57BL/6 mouse.
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- * Researchers found that iPSC generation can occur without reduction even when exposed to ionizing radiation, indicating a unique radio-resistance during early genome reprogramming stages.
- * A transient deficiency in the G1/S cell cycle checkpoint is noted during this process, suggesting similarities in mechanisms between iPSC creation and tumor development, supported by the discovery of specific cancer mutational signatures in these cells.
RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in RNA, the A-repeat has been shown to be essential for its silencing function in differentiating embryonic stem cells. Here, we introduced a new allele into mouse that produces mutated RNA lacking the A-repeat ( ).
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