Publications by authors named "Y Hirao"
Article Synopsis
- To produce high-quality embryos, it's crucial to meet a set of four criteria related to early development and embryo shape.
- Non-essential amino acids, particularly serine, are vital in the culture of bovine embryos; higher concentrations of serine (1,000 µM) significantly boost the formation of compliant blastocysts compared to the standard 100 µM.
- The increase in serine aids in DNA methylation processes essential for embryo growth, while inhibiting serine metabolism leads to fewer methyl donors and reduced blastocyst formation.
Beta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development. Beta-catenin is thought to exert such functions through complexes formed with various proteins. Although β-catenin complex proteins have been identified in several bilaterians, little is known about the structural and functional properties of β-catenin complexes in early metazoan evolution.
View Article and Find Full Text PDFPenicillium brasilianum is an environmental filamentous fungus with useful applications in biotechnology. However, human infections caused by P. brasilianum are rare and not well understood.
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- * The article reviews the common pathophysiology of HF and MASLD and assesses the available treatments, emphasizing guideline-directed medication therapy (GDMT) which includes ACE inhibitors, ARBs, beta-blockers, and other medications.
- * Recent studies suggest that some GDMT medications beneficially impact both HF and MASLD, but further research is needed to validate the effectiveness of other treatments and novel therapies for these conditions.
Cardiovascular diseases (CVD) have imposed a substantial burden on population health and society. In Japan, the National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, grounded in national legislation, seeks to improve the quality of care and standardize treatment for cerebrovascular disease and CVD. The plan emphasizes the need to develop standardized systems for collecting and disseminating medical information, as well as promoting data-driven research.
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