Publications by authors named "Y Henry"
The ribosome maturation factor Rea1 (or Midasin) catalyses the removal of assembly factors from large ribosomal subunit precursors and promotes their export from the nucleus to the cytosol. Rea1 consists of nearly 5000 amino-acid residues and belongs to the AAA+ protein family. It consists of a ring of six AAA+ domains from which the ≈1700 amino-acid residue linker emerges that is subdivided into stem, middle and top domains.
View Article and Find Full Text PDFArticle Synopsis
- Intrinsically disordered regions (IDRs) are abundant in nucleolar proteins but their specific role in ribosome assembly is not well understood.
- The study demonstrates that lysine-rich IDRs in small nucleolar ribonucleoprotein particles (snoRNPs) aid in the modification of precursor rRNA and play a crucial role in nucleolar organization during stress.
- The findings suggest that these IDRs might serve as an evolutionary regulatory mechanism, allowing eukaryotic cells to adapt nucleolar structure based on rRNA production needs.
Ribosome synthesis is a complex process that involves a large set of protein -acting factors, among them DEx(D/H)-box helicases. These are enzymes that carry out remodelling activities onto RNAs by hydrolysing ATP. The nucleolar DEGD-box protein Dbp7 is required for the biogenesis of large 60S ribosomal subunits.
View Article and Find Full Text PDFPurpose: To evaluate the performance of different probabilistic classifiers to predict posterior capsule rupture (PCR) prior to cataract surgery.
Methods: Three probabilistic classifiers were constructed to estimate the probability of PCR: a Bayesian network (BN), logistic regression (LR) model, and multi-layer perceptron (MLP) network. The classifiers were trained on a sample of 2 853 376 surgeries reported to the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO) between 2008 and 2018.