Publications by authors named "Y Hatsukawa"
Article Synopsis
- A study was conducted to explore the link between retinopathy of prematurity (ROP) and continuous oxygen saturation measurements (SpO) in infants born before 30 weeks of gestation in Japan, aiming to create a risk prediction model for severe ROP.
- Data from 350 infants were analyzed, revealing that 23.7% needed treatment for ROP, and significant differences in SpO levels were observed between those requiring treatment and those who didn’t.
- The developed model, which combined birth data and SpO metrics, showed good predictive ability but did not surpass the effectiveness of a simpler model that only included birth weight and gestational age.
We previously reported that our sugar-conjugated platinum complex (cis-dichloro [(2-fluoro-α-d-glucopylanosidyl) propane-1,3-diamine] platinum: FGC-Pt) has low toxicity and tumor growth inhibitory effect comparable to that of cisplatin. We focused on radioactive Pt isotopes in order to analyze the kinetics of FGC-Pt using gamma-ray imaging techniques, assuming that FGC-Pt could be used for chemotherapy in the future. Therefore, in this study, we aimed to develop a non-invasive method to analyze the biodistribution of FGC-Pt using Pt-labeled FGC-Pt ([Pt]FGC-Pt).
View Article and Find Full Text PDFLeber congenital amaurosis (LCA), although rare, is one of the most severe forms of early-onset inherited retinal dystrophy (IRD). Here, we review the molecular genetics and phenotypic characteristics of patients with associated IRD. The longitudinal clinical and molecular findings of a Japanese girl diagnosed with LCA associated with pathogenic variants in c.
View Article and Find Full Text PDFPurpose: To evaluate differences in the progression pattern among subtypes of retinopathy of prematurity (ROP).
Design: Retrospective cohort study.
Participants: Premature infants screened for ROP.
Objective: To investigate factors associated with development of severe retinopathy of prematurity (ROP) in extremely preterm (EP) infants.
Study Design: This retrospective cohort study included 213 EP infants (22 + 0 to 27 + 6 weeks gestation) who were admitted to the neonatal intensive care unit of Osaka Women's and Children's Hospital between 2009 and 2017. Multivariable logistic regression analysis was used to identify neonatal factors associated with severe ROP requiring treatment.