Publications by authors named "Y Hanakawa"
IL-22 induces STAT3 phosphorylation and mediates psoriasis-related gene expression. However, the signaling mechanism leading from pSTAT3 to the expression of these genes remains unclear. We focused on Bcl-3, which is induced by STAT3 activation and mediates gene expression.
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- Paraneoplastic pemphigus (PNP) is an autoimmune disease that leads to severe mucosal erosions and skin lesions, often linked with certain cancers like B-cell lymphoma.
- A 59-year-old Japanese woman with PNP presented severe oral, ocular, and vaginal erosions, along with skin blistering, and was diagnosed with B-cell lymphoma, which went into remission after receiving R-CHOP treatment.
- Despite improvement in her skin condition, the patient's mucosal erosions and bronchiolitis obliterans worsened, ultimately leading to her death after 6 months, indicating the complexity of treating PNP alongside underlying malignancies.