Publications by authors named "Y Hagiwara"
A 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) awareness could help prevent disease progression through modifiable risk factors. However, few patients with CKD are aware of their disease. We aimed to investigate the factors associated with CKD awareness and impact of CKD awareness on renal prognosis.
View Article and Find Full Text PDFThis study aimed to investigate the efficacy of a hypothetical biennial weight management regimen in reducing the necessity for knee replacement (KR) surgery among middle-aged and older adults with or at a higher risk for knee osteoarthritis (OA). Data from the Osteoarthritis Initiative cohort in the US, comprising community-dwelling adults aged 45-79 years at high risk for or with symptomatic knee OA who underwent baseline assessments from September 2008 to December 2010 were used. Subsequent evaluations were conducted at 12, 24, and 96 months.
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- Granulocyte/monocyte adsorption therapy can help treat mild-to-moderate inflammatory bowel disease by removing activated immune cells, and its efficacy was tested using new columns designed for better adsorption.
- In a study with rats suffering from colitis, the new columns led to improved tissue health but didn’t significantly enhance the rate of immune cell adsorption into the blood.
- The therapy was associated with an increase in newly formed B cells that produced higher levels of interleukin-10, suggesting they play a role in reducing inflammation and controlling colitis symptoms.
Design of ancestral mammalian alkaline phosphatase bearing high stability and productivity.
Appl Environ Microbiol
December 2024
Unlabelled: Mammalian alkaline phosphatase (AP) is widely used in diagnostics and molecular biology but its widespread use is impaired because it is difficult to express in and has low thermostability. To overcome these challenges, we employed sequence-based protein redesign methods, specifically full consensus design (FCD) and ancestral sequence reconstruction (ASR), to create APs with enhanced properties. Biochemical analyses revealed that these newly designed APs exhibited improved levels of expression in their active form and increased thermostability compared to bovine intestinal AP isozyme II (bIAPII), without impeding enzymatic activity.
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