Publications by authors named "Y Hagino"
Article Synopsis
- - Increased lactate levels from glycolysis are being studied as potential markers for metabolic changes in neurons, linked to a drop in brain pH, which has been associated with various neuropsychiatric disorders like schizophrenia and autism.
- - Research shows that these pH and lactate changes are common across different animal models, including those for depression, epilepsy, and Alzheimer's disease, though findings vary, particularly within the autism spectrum.
- - A large-scale analysis indicated that higher lactate levels correlate with worse working memory performance, suggesting that altered brain chemistry might reflect underlying conditions across multiple disorders.
The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an increased behavioral response to a drug with repeated administration, can persist for many months after the last administration. Research has shown that the serotonin 1B (5-HT1B) receptor plays a critical role in the development and maintenance of drug addiction, as well as other addictive behaviors.
View Article and Find Full Text PDFBackground: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline mutations of either the TSC1 or TSC2 gene, but somatic mutations were identified in both genes, and the combined effects of TSC1 and TSC2 mutations have been unknown.
Methods: The present study investigated social behaviors by the social interaction test and three-chambered sociability tests, effects of rapamycin treatment, and gene expression profiles with a gene expression microarray in Tsc1 and Tsc2 double heterozygous mutant (TscD) mice.
Article Synopsis
- Dopamine-deficient mice show increased activity that may stem from reduced muscarinic signaling in the brain.*
- In these mice, the density of the M2 muscarinic acetylcholine receptor is decreased in the cortex, potentially impacting acetylcholine levels.*
- Treatments with specific receptor agonists, like xanomeline and arecaidine propargyl ester tosylate, help reduce hyperactivity in these dopamine-deficient mice, indicating the role of certain muscarinic receptors in managing this behavior.*
Article Synopsis
- * Research on dopamine-deficient mice indicated that drugs like quetiapine and donepezil can reduce hyperactivity, suggesting a potential method to study psychiatric symptoms tied to dopamine deficiency.
- * The study revealed that quetiapine helps decrease hyperactivity in these mice potentially via serotonin (5-HT) receptor activation, pointing to the importance of 5-HT receptors in addressing psychiatric symptoms related to dopamine deficiency.