Multiscale Engineered Bionic Solid-State Electrolytes Breaking the Stiffness-Damping Trade-Off.

All-solid-state lithium metal batteries are regarded as next-generation devices for energy storage due to their safety and high energy density. The issues of lithium dendrites and poor mechanical compatibility with electrodes present the need for developing solid-state electrolytes with high stiffness and damping, but it is a contradictory relationship. Here, inspired by the superstructure of tooth enamel, we develop a composite solid-state electrolyte composed of amorphous ceramic nanotube arrays intertwined with solid polymer electrolytes.

Fusing multispectral information for retinal layer segmentation.

Extensive research on retinal layer segmentation (RLS) using deep learning (DL) is mostly approaching a performance plateau, primarily due to reliance on structural information alone. To address the present situation, we conduct the first study on the impact of multi-spectral information (MSI) on RLS. Our experimental results show that incorporating MSI significantly improves segmentation accuracy for retinal layer optical coherence tomography (OCT) images.

Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis.

Liver fibrosis is a prevalent liver disease associated with significant morbidity, and the activation of hepatic stellate cells (HSCs) serves as the primary causative factor driving the progression of liver fibrosis. However, capillarization of liver sinusoidal endothelial cells (LSECs) induced by hepatic fibrosis can reduce nitric oxide (NO) production and bioavailability, which consequently loses the ability to retain HSCs dormant, leading to amplified HSCs activation. Herein, an elaborate micelle (VN-M@BN) loaded with benazepril (BN) was constructed by self-assembly of polymeric NO donor, aiming for the controlled release of NO in liver fibrosis lesions thereby impeding the progression of liver fibrosis.

Knee loading and joint pain during daily activities in people with knee osteoarthritis: A systematic review and meta-analysis.

Background: Knee loading is associated with the severity and progression of knee osteoarthritis, while knee pain contributes to reduced functional ability and quality of life. In this systematic review, we quantified knee loading and knee pain during different daily activities in people with knee osteoarthritis and explored methodological reasons for differences between studies.

Methods: PubMed, Web of Science, Scopus, and manual searches were performed up to July 2024, to retrieve studies measuring knee loading and knee pain in walking, sit-to-stand and stair climbing of people with knee osteoarthritis.

Degradation of 15 halogenated hydrocarbons by 5 unactivated chemical oxidation oxidants.

Oxidants used in the ISCO technology usually require activation by activators to degrade contaminants. However, this study investigated degradation of 15 typical halogenated hydrocarbons by five common ISCO oxidants (PS, PMS, HO, KMnO, SPC) without activation in both pure water and real groundwater. Unactivated PS could degrade 14 halogenated hydrocarbons, excluding tetrachloromethane.