mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction.

Th17 cells are activated by STAT3 factors in the nucleus, and these factors are correlated with the pathologic progression of rheumatoid arthritis (RA). Recent studies have demonstrated the presence of STAT3 in mitochondria, but its function is unclear. We investigated the novel role of mitochondrial STAT3 (mitoSTAT3) in Th17 cells and fibroblast-like synoviocytes (FLSs) and analyzed the correlation of mitoSTAT3 with RA.

The intersection of finTech adoption, HR competency potential, service innovation, and firm growth in the banking sectors using Entropy and TOPSIS.

The adoption of Financial Technology (FinTech), along with the enhancement of Human Resource (HR) competencies, service innovation, and firm growth, plays a crucial role in the development of the banking sector. Despite their importance, obtaining reliable results is often challenging due to the complex, high-dimensional correlations among various features that affect the industry. To address this issue, this research introduces a hybrid Multi-Criteria Decision-Making (MCDM) model that integrates the Entropy-Weighted Method (EWM) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS).

Estimating hip impact velocity and acceleration from video-captured falls using a pose estimation algorithm.

Analyzing video footage of falls in older adults has emerged as an alternative to traditional lab studies. However, this approach is limited by the labor-intensive process of manually labeling body parts. To address this limitation, we aimed to validate the use of the AI-based pose estimation algorithm (OpenPose) in assessing the hip impact velocity and acceleration of video-captured falls.

Ribosomal proteins mediate non-canonical regulation of gut inflammatory signature by crop contaminant deoxynivalenol.

Deoxynivalenol (DON), a prevalent mycotoxin produced by Fusarium species, contaminates global agricultural products and poses significant health risks, particularly to the gastrointestinal (GI) system. DON exposure disrupts ribosomal function, inducing stress responses linked to various inflammatory diseases, including inflammatory bowel disease (IBD). In this study, we elucidate a novel regulatory mechanism involving ribosomal proteins (RPs) RPL13A and RPS3, which mediate proinflammatory chemokine production in DON-exposed gut epithelial cells.