Uncovering Novel Drugs that Restore Vision Using Orthogonal Pooling in Zebrafish.

Photoreceptor and retinal pigment epithelium (RPE) dysfunction in inherited retinal degenerations (IRDs) and age-related macular degeneration (AMD) necessitate innovative therapies to preserve vision. Vision impairment incurs a substantial global economic burden, with the World Health Organization reporting an annual global productivity loss of approximately $411 billion. Current treatments are limited, underscoring the urgency for novel solutions.

Clinicopathological comparison of benign eyelid tumours in tertiary care centers in Lima and Montreal from 2010 to 2019.

Objective: The eyelids are complex structures composed of various tissues. As such, a wide array of lesions exist that affect the eyelids. Clinical diagnosis of these lesions is essential to differentiate benign from malignant ones.

Evaluation of the Effect of Momelotinib on Cardiac Repolarization: A Thorough QT Study.

A randomized, partially blinded, placebo-controlled, crossover study in 48 healthy adults assessed the effect of momelotinib on the heart rate-corrected QT interval (QTc) using the Fridericia formula (QTcF). QTc was evaluated for momelotinib 200 mg (therapeutic dose), momelotinib 800 mg (supratherapeutic dose), moxifloxacin 400 mg (positive control), and placebo. Pharmacokinetic profiles of momelotinib and its active metabolite M21 were evaluated.

Incidence and Risk Factors for Amputations in Persons with Diabetes Mellitus: A Retrospective Cohort Study.

The aim of this study was to identify and analyze the incidence rate of amputations and their risk factors in people with Diabetes Mellitus (DM) in two specialized outpatient clinics in Brazil. This is an epidemiological, retrospective cohort study using data collected from electronic health records of 281 adult diabetic patient types 1 or 2; attended in specialized outpatient service between 2015 and 2020. Statistical analyses were performed using the 2 sample t-test or Wilcoxon-Mann-Whitney test, for quantitative variables, and the Pearson's χ2 test or Fisher's exact test for categorical variables.

Gut bacteria-derived succinate induces enteric nervous system regeneration.

Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion . Disruptions in microbial communities caused by antibiotics or enteric infections result in the loss of enteric neurons and long-term motility disorders . However, the signals and underlying mechanisms of this microbiota-neuron communication are unknown.