Publications by authors named "Y H Chong"
: Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder characterized by intermittent upper airway obstruction, leading to significant health consequences. Traditional diagnostic methods, such as polysomnography, are time-consuming and resource-intensive. : This study explores the potential of proton-transfer-reaction mass spectrometry (PTR-MS) in identifying volatile organic compound (VOC) biomarkers for the non-invasive detection of OSA.
View Article and Find Full Text PDFPurpose: To investigate how obesity affects the pharmacokinetics of biologics in a rat model.
Method: Male Long-Evans rats were fed a high-fat diet from the age of 3 weeks and development of obesity was monitored by measuring body size and composition (fat and lean mass). The animals received nivolumab (1 and 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) by intravenous or subcutaneous injection.
Background: Apolipoproteins as an integral part of lipoproteins are crucial for the transport and metabolism of lipids. However, there is a lack of longitudinal studies to quantify the concentrations of maternal apolipoproteins from preconception to postpartum and their associations with maternal metabolic health and offspring birth outcomes.
Methods: Quantification of apolipoproteins was performed on maternal plasma samples (N = 243 trios) collected at preconception, 26-28 weeks' pregnancy, and three months postpartum in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort study.
Clinical study on deciduous fused teeth and inherited permanent teeth.
Hua Xi Kou Qiang Yi Xue Za Zhi
February 2025
Objectives: This study aimed to investigate the clinical characteristics of deciduous fused teeth and their inherited permanent-tooth performance type by using panoramic radiographs.
Methods: A total of 14 404 panoramic radiographs of 3- to 6-year-old children with deciduous dentition were collected from January 2023 to July 2024. The incidence of deciduous fused teeth was observed, and the abnormality of permanent teeth was recorded.
Life stage impact on the human skin ecosystem: lipids and the microbial community.
NPJ Biofilms Microbiomes
January 2025
Article Synopsis
- The study examines the relationship between skin oxylipins, which are bioactive lipids produced from fatty acids by skin microbes, and different microbial communities on the skin of children and adults.
- Findings highlighted that Malassezia restricta, a type of skin fungus, has a positive impact on the production of a specific oxylipin (9,10-DiHOME) in adults, while showing a negative correlation with its precursor in children, indicating differences in skin chemistry across age groups.
- The research suggests a complex communication system between skin microbes and host lipid metabolism that could have implications for skin health, emphasizing the need for further exploration of these interactions for potential therapeutic applications.