Fecal fatty acid profile reveals the therapeutic effect of red ginseng acidic polysaccharide on type 2 diabetes mellitus in rats.

This study aimed to investigate the potential hypoglycemic mechanism of red ginseng acidic polysaccharides (RGAP) from the perspective of fatty acid (FA) regulation. A high-glucose/high-fat diet in conjunction with streptozotocin administration was employed to establish type 2 diabetes mellitus (T2DM) rat models, and their fecal FAs were detected using the liquid chromatography-mass spectrometry (LC-MS) method. RGAP treatment alleviated the polyphagia, polydipsia, weight loss, and hyperglycemia observed in T2DM rats.

Influence of diabetes mellitus on metabolic networks in lung cancer patients: an analysis using dynamic total-body PET/CT imaging.

Introduction: The intricate interplay between organs can give rise to a multitude of physiological conditions. Disruptions such as inflammation or tissue damage can precipitate the development of chronic diseases such as tumors or diabetes mellitus (DM). While both lung cancer and DM are the consequences of disruptions in homeostasis, the relationship between them is intricate.

Multi-Vortex Regulation in a Simple Semicircular Microchannel with Ordered Micro-Obstacles for High-Throughput Buffer Exchange.

Microfluidics is an emerging technology for buffer exchange in bioprocessing applications. However, achieving buffer exchange with simplicity of operation and high throughput in a straightforward channel design remains a challenge. This study presents a novel semicircular microchannel design that allows for the deterministic regulation of helical and Dean vortices through geometric confinement.

m6A demethylase Fto inhibited macrophage activation and glycolysis in diabetic nephropathy via m6A/Npas2/Hif-1α axis.

Macrophage infiltration and activation is a key factor in the progression of diabetic nephropathy (DN). However, aerobic glycolysis induced by m6A methylation modification plays a key role in M1-type activation of macrophages, but the specific mechanism remains unclear in DN. In this study, the expression of m6A demethylase Fto in bone marrow derived macrophages and primary kidney macrophages from db/db mice.

The Novel Role of GDI2: A Mini-Review.

GDP Dissociation Inhibitor 2 (GDI2) plays a crucial role in maintaining cellular homeostasis by regulating Rab GTPases involved in vesicular transport. This review highlights the importance of GDI2 in various biological processes, particularly embryonic development, apoptosis regulation, cancer, and immune responses. GDI2's essential function in embryonic development is evidenced by the embryonic lethality observed in GDI2 knockout mice.