Publications by authors named "Y Gueguen"
The increase in marine diseases, particularly in economically important mollusks, is a growing concern. Among them, the Pacific oyster (Crassostrea gigas) production faces challenges from several diseases, such as the Pacific Oyster Mortality Syndrome (POMS) or vibriosis. The microbial education, which consists of exposing the host immune system to beneficial microorganisms during early life stages is a promising approach against diseases.
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- - Polymicrobial infections, like Pacific Oyster Mortality Syndrome (POMS), are complex and under-researched, involving interactions between the ostreid herpesvirus 1 (OsHV-1) and harmful bacteria impacting oyster populations on the French Atlantic coast.
- - Field studies and laboratory experiments revealed that certain bacterial communities flourish in oysters infected with OsHV-1 and that these bacteria can enhance the virus's effects, leading to accelerated oyster mortality.
- - Cooperative behaviors among bacteria, including promoting one another’s growth and sharing resources, play a significant role in the severity of POMS, suggesting that targeting these interactions may help manage the disease and protect oyster health.
Article Synopsis
- Disease emergence is increasing due to global changes, making it crucial to understand how host populations adapt rapidly, particularly in the context of Pacific oyster mortality syndrome (POMS).
- The study used (epi)genome-wide association mapping to reveal that oysters exposed to POMS showed signs of genetic and epigenetic selection, particularly in genes related to immunity.
- Results indicated that about one-third of the phenotypic variation in response to POMS could be attributed to interactions between genetic and epigenetic factors, highlighting the significant role of both in rapid adaptation to infectious diseases.
Article Synopsis
- The Pacific oyster Crassostrea gigas faces a deadly condition known as Pacific Oyster Mortality Syndrome (POMS), triggered by the herpesvirus OsHV-1 µVar, leading to an opportunistic bacterial infection.
- Researchers combined metabarcoding and metatranscriptomic techniques to investigate POMS, discovering a consistent progression of disease and identifying a core group of bacteria that, along with the virus, contribute to the syndrome.
- The identified bacteria exhibit low competition for nutrients, which might enhance their ability to colonize the oyster's tissues and maintain the POMS pathobiota despite varying environmental challenges.
During nuclear fuel processing, workers can potentially be exposed to repeated inhalations of uranium compounds. Uranium nephrotoxicity is well documented after acute uranium intake, but it is controversial after long-term or protracted exposure. This study aims to analyze the nephrotoxicity threshold after repeated uranium exposure through upper airways and to investigate the resulting uranium biokinetics in comparison to reference models.
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