Publications by authors named "Y Gielchinsky"
Fetal surgery presents distinctive anesthetic challenges due to the need to balance maternal and fetal safety. This retrospective study evaluates the anesthetic management strategies used at a single center for various fetal interventions, including fetoscopic laser photocoagulation, fetal endoluminal tracheal occlusion, bipolar cord coagulation, and fetoscopic spina bifida repair. We reviewed 195 fetal procedures performed between 2019 and 2023 at Rabin Medical Center.
View Article and Find Full Text PDFHepatocyte regeneration is driven by embryo-like DNA methylation reprogramming.
Proc Natl Acad Sci U S A
April 2024
Article Synopsis
- After partial hepatectomy, the liver can rapidly regenerate, involving significant changes in DNA methylation patterns.
- These changes mimic the methylation state of embryonic liver cells, indicating that adult liver cells undergo epigenetic dedifferentiation during regeneration.
- The study suggests that understanding these methylation processes could inform strategies in regenerative medicine by highlighting the importance of early embryonic gene behavior in liver regeneration.
Unlabelled: To evaluate the effectiveness of a novel protocol, adopted in our institution, as a quality improvement project for congenital diaphragmatic hernia (CDH). A maximal lung protection (MLP) protocol was implemented in 2019. This strategy included immediate use of high-frequency oscillatory ventilation (HFOV) after birth, during the stay at the Neonatal Intensive Care Unit (NICU), and during surgical repair.
View Article and Find Full Text PDFPurpose: To provide a comprehensive report of the experience gained in the prenatal treatment of congenital diaphragmatic hernia (CDH) using fetoscopic endoluminal tracheal occlusion (FETO) following its implementation at a newly established specialized fetal medicine center.
Methods: Mothers of fetuses with severe CDH were offered prenatal treatment by FETO.
Results: Between 2018 and 2021, 16 cases of severe CDH underwent FETO.
Perinatal outcome of monochorionic triamniotic triplet pregnancy: multicenter cohort study.
Ultrasound Obstet Gynecol
October 2023
Objective: Monochorionic (MC) triplet pregnancies are extremely rare and information on these pregnancies and their complications is limited. We aimed to investigate the risk of early and late pregnancy complications, perinatal outcome and the timing and methods of fetal intervention in these pregnancies.
Methods: This was a multicenter retrospective cohort study of MC triamniotic (TA) triplet pregnancies managed in 21 participating centers around the world from 2007 onwards.