Publications by authors named "Y Ghasemi"
Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long ncRNAs (lncRNAs), are essential regulators of processes, such as the cell cycle and apoptosis. In addition to interacting with intracellular complexes and participating in diverse molecular pathways, ncRNAs can be used as clinical diagnostic biomarkers and therapeutic targets for fighting cancer. Studying ncRNA gene clusters is crucial for understanding their role in cancer and developing new treatments.
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- - A novel compound called (2,4-Dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1-benzo[]imidazole-6-carboxamide (5o) was created and tested for its effectiveness in killing human cancer cells (A549 and SW480) compared to normal cells (MRC-5) using the MTT assay.
- - Compound 5o demonstrated exceptional cytotoxicity with very low effective concentrations (IC values of 0.15 μM for A549 and 3.68 μM for SW480), significantly outperforming standard cancer treatments like cisplatin, etoposide, and doxorubicin.
- - The study
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- Human cytomegalovirus (HCMV) can cause severe health issues, especially in those with weakened immune systems, and current diagnostic tests for HCMV have limitations in sensitivity and specificity.
- Researchers aimed to create a new, more accurate multi-epitope antigen for diagnosing HCMV infections using immunoinformatic methods, selecting five key proteins based on their antigenic properties.
- The designed antigen showed promising stability and antigenicity without cross-reactivity and is a potential candidate for better HCMV diagnosis, although further lab testing is needed to confirm its effectiveness.*
Significant progress has been made in HIV-1 research; however, researchers have not yet achieved the objective of eradicating HIV-1 infection. Accordingly, in this study, eucaryotic and procaryotic in silico vaccines were developed for HIV-Gag polyproteins from 100 major HIV subtypes and CRFs using immunoinformatic techniques to simulate immune responses in mice and humans. The epitopes located in the conserved domains of the Gag polyprotein were evaluated for allergenicity, antigenicity, immunogenicity, toxicity, homology, topology, and IFN-γ induction.
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