Publications by authors named "Y Geffen"

Physical activity reduces cancer-associated mortality through multiple mechanisms, including tumor immune microenvironment (TIME) reprogramming. However, whether and how physiological interventions promote anti-tumor immunity remain elusive. Here, we report that clinically relevant voluntary exercise promotes muscle-derived extracellular vesicle (EV)-associated miR-29a-3p for tumor extracellular matrix (ECM) inhibition in patients and mouse models, thereby permitting immune cell infiltration and immunotherapy.

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Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, and therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes.

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  • NK cells play a crucial role in cancer immune defense by providing a fast response to tumors, allowing for direct attacks on cancer cells without needing prior antigen recognition.
  • * Gamida Cell's NAM platform aims to boost the effectiveness of NK cells, particularly in treating multiple myeloma (MM) by targeting CD38, a protein common on MM cells.
  • * Researchers have used CRISPR technology to create genetically modified NK cells that lack CD38 and have enhanced abilities to target MM cells, achieving a significant reduction in self-destruction among NK cells during treatment.
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  • DNA methylation is crucial for maintaining cellular identity, but it's often disrupted in tumors and linked with other genetic changes.
  • Researchers analyzed 687 tumors and adjacent normal tissues across various organs to create a Pan-Cancer catalog, highlighting specific methylation patterns.
  • They discovered that certain methylation changes are associated with cancer characteristics, such as hypomethylated FGFR2 in endometrial cancer and hypermethylated STAT5A leading to immune suppression in squamous tumors, revealing the importance of methylation in tumor behavior.
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  • Post-translational modifications (PTMs) significantly influence cell signaling and physiology in both healthy and cancerous cells, with recent advancements in mass spectrometry allowing for precise analysis of these modifications.* -
  • This study utilizes the largest dataset of proteogenomics from 1,110 cancer patients to uncover widespread patterns of protein changes, particularly focusing on acetylation and phosphorylation across 11 cancer types.* -
  • Findings show that specific cancer types exhibit unique PTM-related alterations linked to processes like DNA repair, immune response, kinase activity, and histone regulation, suggesting new potential therapeutic targets.*
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