Publications by authors named "Y Ganor"
Erratum for Barbosa Bomfim et al., "CGRP inhibits SARS-CoV-2 infection of bronchial epithelial cells, and its pulmonary levels correlate with viral clearance in critical COVID-19 patients".
J Virol
December 2024
Herpes simplex virus 1 (HSV-1) latently infected neurons display diverse patterns in the distribution of the viral genomes within the nucleus. A key pattern involves quiescent HSV-1 genomes sequestered in promyelocytic leukemia nuclear bodies (PML NBs) forming viral DNA-containing PML-NBs (vDCP NBs). Using a cellular model that replicates vDCP NB formation, we previously demonstrated that these viral genomes are chromatinized with the H3.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines the role of calcitonin gene-related peptide (CGRP) in critical COVID-19 patients, finding that levels of CGRP are elevated in both the plasma and lungs during the early stages of infection with SARS-CoV-2.
- - CGRP and its stable analog, SAX, were found to inhibit the infection of bronchial cells by SARS-CoV-2 variants in a dose-dependent manner, suggesting that CGRP plays a protective role against the virus.
- - The research indicates that increased CGRP levels may help in viral clearance by directly inhibiting SARS-CoV-2 replication, which opens potential avenues for CGRP-based therapies in managing COVID-19.
The effects of the secondary processes of Hot Isostatic Pressing (HIP) at 920 °C and Heat Treatment (HT) at 1000 °C of Electron Beam-Melted (EBM) Ti-6Al-4V alloy on the microstructure and hydrogen embrittlement (HE) after electrochemical hydrogen charging (EC) were investigated. Comprehensive characterization, including microstructural analysis, X-ray diffraction (XRD), thermal desorption analysis, and mechanical testing, was conducted. After HIP, the β-phase morphology changed from discontinuous Widmanstätten to a more continuous structure, 10 times and ~1.
View Article and Find Full Text PDFUpon its mucosal transmission, HIV type 1 (HIV-1) rapidly targets genital antigen-presenting Langerhans cells (LCs), which subsequently transfer infectious virus to CD4 T cells. We previously described an inhibitory neuroimmune cross talk, whereby calcitonin gene-related peptide (CGRP), a neuropeptide secreted by peripheral pain-sensing nociceptor neurons innervating all mucosal epithelia and associating with LCs, strongly inhibits HIV-1 transfer. As nociceptors secret CGRP following the activation of their Ca ion channel transient receptor potential vanilloid 1 (TRPV1), and as we reported that LCs secret low levels of CGRP, we investigated whether LCs express functional TRPV1.
View Article and Find Full Text PDF