Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis.

Introduction: Neutrophils are initial responders in inflammation and contribute to non-alcoholic fatty liver disease (NAFLD) progression to steatohepatitis (NASH). Neutrophil extracellular traps (NETs) are implicated in liver injury, yet their precise mechanisms in NASH progression remains unclear.

Objectives: This study investigates how NETs drive NASH progression by disrupting hepatocyte lipotoxicity and explore the regulatory mechanism of NETs formation and its downstream effects on liver pathology.

Transapical Transcatheter Aortic Valve Implantation with the J-Valve System in Aortic Regurgitation.

Background: Aortic regurgitation (AR) is a condition associated with significant morbidity and mortality, particularly in severe cases. The J-Valve system, next-generation transcatheter heart valve, may overcome the procedural challenges associated with treating pure AR. This study reported the outcome of use of the J-Valve for treatment of AR.

The impact of low-protein diet on residual renal function in dialysis patients: a systematic review and metaanalysis.

Objective: A low-protein diet is essential for the nutritional management of chronic kidney diseases as it can reduce renal burden. However, the effect of low-protein diets on dialysis patients compared to pre-dialysis patients remains unclear. This study aims to compare residual renal function among dialysis patients following a low-protein diet versus a normal diet, offering valuable insights into the optimal nutritional strategy for preserving residual renal function.

Supramolecular nanoagent as a dual-blocked thermoresistance inhibitor for effective mild-temperature photothermal therapy.

Mild-temperature (<45 °C) photothermal therapy (PTT) is a promising approach to kill cancer cells by inhibiting the expression of heat shock proteins (HSPs) related to thermoresistance, a method commonly applied in most mild-temperature PTT studies. Regrettably, thermoresistance cannot be fully suppressed solely by inhibiting HSPs. Under normal conditions, heat shock factor 1 (HSF-1) remains inactive and forms a complex with HSPs.