Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy.

Tumor-specific T cells play a vital role in potent antitumor immunity. However, their efficacy is severely affected by the spatiotemporal orchestration of antigen-presentation as well as the innate immune response in dendritic cells (DCs). Herein, we develop a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform (DIPNP) to encapsulate ovalbumin (OVA) via electrostatic interaction when the nanocarrier serves as both STING agonist and immune adjuvant in DCs.

Exploration of Body Image in Postoperative Patients With Oral Cancer: An Exploratory Sequential Mixed Methods Study.

Background: Postoperative patients with oral cancer are deeply distressed about their body image. However, their true inner feelings and the factors influencing body image remain unclear.

Aims: This study aims to investigate the experience of body image disturbance in patients 3 months after oral cancer surgery and analyze the influencing factors.

A nomogram for predicting survival in patients with primary testicular lymphoma: A population-based study.

Background: Primary testicular lymphoma (PTL) is a rare malignancy whose epidemiology and prognosis have not been studied.

Materials And Methods: PTL patient data were collected from the SEER online database, and the data were divided into a training cohort and a validation cohort according to random assignment. The training cohort was subjected to a one-way COX regression analysis, and statistically significant differences were included in the multi-factor COX regression analysis and constructed nomograms.

Novel biopolymer-based active packaging material for chilled beef applications: Collagen peptide-astragaloside nanocomplexes incorporated into oxidized hydroxypropyl starch/chitosan films.

The present study intended to investigate the properties of collagen peptide (CP)-astragaloside (AG) nanocomplexes (CPANs) improved oxidized hydroxypropyl starch (OHS)/chitosan (CS) (OC) film and to explore the preservation of chilled beef. The results indicated that AG significantly enhanced the stability, antioxidant capacity, and antibacterial properties of CP through mechanisms like static quenching and hydrophobic interactions. The incorporation of CPANs improved thickness, swellability, and water vapor blocking, UV-blocking and mechanical properties, antioxidant and antibacterial activity of OC film.

Disinfection efficacy of peroxyacetic acid against bacterial spores.

Peracetic acid (PAA) is an emerging disinfectant known to be highly effective against various microorganisms. However, the capability of PAA to eliminate spores under different conditions and its application in liquid and gaseous forms remain unclear. Here, we aimed to develop a stabilized single-composite PAA and evaluate its disinfection efficacy in both liquid and gaseous form against suspended or surface-coated spores under varying temperature and humidity conditions.