Publications by authors named "Y Futoh"
Article Synopsis
- - This study investigates a new method for treating peritoneal metastasis (PM) by using AAV vectors to deliver a tumor-suppressing microRNA, miR-29b, to cells in the peritoneum, which is the lining of the abdominal cavity.
- - The research shows that AAV-DJ serotype effectively boosts miR-29b levels in peritoneal mesothelial cells, leading to reduced tumor cell attachment and decreased fibrosis, especially after a single intraperitoneal injection.
- - Furthermore, the combination of miR-29b delivery with traditional chemotherapy, like paclitaxel, improves treatment outcomes by inhibiting the growth of established PM from gastric and pancreatic cancers.
The vagus nerve is the only pathway for transmitting parasympathetic signals between the brain and thoracoabdominal organs, thereby exhibiting anti-inflammatory functions through the cholinergic anti-inflammatory pathway. Despite often being resected during lymph node dissection in upper gastrointestinal cancer surgery, the impact of vagotomy on postoperative outcomes in gastric cancer patients remains unclear. Sub-diaphragmatic vagotomy was performed on C57BL/6 mice.
View Article and Find Full Text PDFThe spleen is a key source of circulating and tumor-infiltrating immune cells. However, the effect of splenectomy on tumor growth remains unclear. At 3 weeks after splenectomy, we subcutaneously injected LuM1 cells into BALB/c mice and evaluated the growth of primary tumors and lung metastases at 4 weeks after tumor inoculation.
View Article and Find Full Text PDFBackground: Low-density granulocytes (LDGs) have been shown to be increased in the peripheral blood of patients with inflammatory and malignant diseases. This study evaluated LDGs in patients who underwent radical surgery for colorectal cancer (CRC) and their impact on survival.
Methods: Patients who underwent radical colectomy between 2017 to 2021 were screened for enrolment in the study.
Aim: The clinical efficacy of chemoradiotherapy (CRT) is largely dependent on host immune status. The aim of this study was to identify possible markers expressed on circulating mononuclear cells to predict tumour response in patients with locally advanced rectal cancer (LARC).
Methods: Peripheral blood samples were obtained from 47 patients diagnosed with LARC before and after CRT.