Publications by authors named "Y Funasaka"
Article Synopsis
- - Vitiligo, an autoimmune skin disease causing loss of pigment, was studied in adult Japanese patients to understand the impact of dietary habits on its development, focusing on factors like BMI and nutrient intake compared to healthy controls.
- - The study found that vitiligo patients had a higher BMI and lower consumption of certain nutrients like manganese and vitamin D, with significant correlations between male sex, age, dietary intake, and the severity of vitiligo symptoms.
- - Results suggest managing obesity may help prevent or treat vitiligo, as specific dietary habits were linked to higher disease severity in differing body areas.
Article Synopsis
- Cysteamine isobionic-amide, a new depigmenting agent, was tested against the gold standard treatment, Modified Kligman's formula (mKF), for melasma in a clinical trial involving 80 patients.
- Both treatments demonstrated equivalent effectiveness in reducing melasma severity at weeks 4 and 16, but cysteamine showed significantly higher patient satisfaction and quality of life improvements.
- The study suggests that cysteamine isobionic-amide is a promising alternative to mKF for long-term melasma treatment, offering a faster onset of action and fewer side effects.
Senile lentigo (SL) is a pigmentary disorder associated with disrupted epidermal turnover. Trace minerals in the skin are known to regulate keratinocyte proliferation and differentiation. To clarify the role of iron in SL, we compared the expression of molecules related to iron metabolism between SL lesion (lesion) and the surrounding normal skin (nonlesion).
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- Psoriasis is a chronic skin condition characterized by inflammation driven by interleukin 17 and increased skin cell production, and a high-fiber diet can potentially help manage this condition.
- In a study, a high-fiber diet (HFD) led to reduced skin thickening and inflammation in mice with psoriasis-like symptoms, showing significant changes in various inflammatory markers.
- The diet appeared to influence the gut microbiome, increasing beneficial bacteria that produce short-chain fatty acids like propionate, which further reduced inflammation and could aid in developing new treatments for psoriasis.