Publications by authors named "Y Foucher"

Background: Islet transplantation has been associated with better metabolic control and quality of life than insulin treatment alone, but direct evidence of its effect on hard clinical endpoints is scarce. We aimed to assess the effect of islet transplantation on patient-graft survival in kidney transplant recipients with type 1 diabetes.

Methods: In this retrospective cohort study, we enrolled all patients with type 1 diabetes who received a kidney graft in France during the study period, identified from the CRISTAL nationwide registry.

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Purpose: Mortality is often assessed during ICU stay and early after, but rarely at later stage. We aimed to compare the long-term mortality between TBI and ICH patients.

Materials And Methods: From an observational cohort, we studied 580 TBI patients and 435 ICH patients, admitted from January 2013 to February 2021 in 3 ICUs and alive at 7-days post-ICU discharge.

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Background: In relapsing-remitting multiple sclerosis (RRMS), early identification of suboptimal responders can prevent disability progression.

Objective: We aimed to develop and validate a dynamic score to guide the early decision to switch from first- to second-line therapy.

Methods: Using time-dependent propensity scores (PS) from a French cohort of 12,823 patients with RRMS, we constructed one training and two validation PS-matched cohorts to compare the switched patients to second-line treatment and the maintained patients.

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Article Synopsis
  • The COVID-19 pandemic led to global kidney transplantation (KT) moratoriums, creating uncertainty about their effects on the life expectancy of KT candidates.
  • A study simulated various populations of French KT candidates, analyzing potential outcomes based on moratorium lengths of 0 to 24 months, using data from nearly 64,000 patients.
  • Findings indicated that even a short 2.5-month moratorium predicted additional waiting list time and deaths, with significant impacts observed for moratoriums longer than 9 months, suggesting that extending the moratorium could have severe consequences for patient outcomes.
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Barbiturates are proposed as a second/third line treatment for intracranial hypertension in traumatic brain injury (TBI) patients, but the literature remains uncertain regarding their benefit/risk balance. We aimed to evaluate the impact of barbiturates therapy in TBI patients with early intracranial hypertension on the intensive care unit (ICU) survival, the occurrence of ventilator-associated pneumonia (VAP), and the patient's functional status at three months. We used the French AtlanREA prospective cohort of trauma patients.

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