Publications by authors named "Y Forsell"
Article Synopsis
- Lifestyle habits significantly impact premature death, and the Swedish health dialogues model aims to improve these habits through primary care and community efforts.
- A systematic review of seven studies concluded that this model effectively reduces premature mortality, blood pressure, and other health markers with moderate evidence.
- Combining health dialogues with community initiatives led to even greater health benefits, especially in improving dietary habits.
Associations between the fat mass and obesity-associated (FTO) gene and obesity are well-established. However, recent studies have linked FTO to addiction phenotypes and dopaminergic signaling, thus suggesting broader psychiatric implications. We explored this assumption by conducting a phenome-wide association study across 4756 genome-wide association studies, identifying 23-26 psychiatric traits associated with FTO at the multiple-corrected significance level.
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- The study investigates the link between the gut microbiome and schizophrenia spectrum disorders (SSD), analyzing feces from 52 young adult SSD patients and 52 controls using advanced sequencing techniques.
- Results showed that SSD patients had lower α-diversity and distinct β-diversity in their gut bacteria compared to controls, highlighting significant differences in both bacterial species and gene functions.
- Machine learning classifiers effectively distinguished SSD patients from healthy individuals based on their gut microbiome data, indicating potential biomarkers and further supporting the idea of microbiome alterations in SSD.
Article Synopsis
- Body weight dissatisfaction is prevalent among individuals with obesity, and this study aimed to examine the factors influencing the differences between current BMI, desired BMI, and an ideal BMI of 25 kg/m2.
- The research involved 10,441 randomly selected Swedish participants who reported their weight, height, desired weight, and factors like depressive symptoms and alcohol intake, focusing on a subgroup of 808 individuals with obesity.
- Results indicated that women with obesity and those with major depression had significantly larger discrepancies between current and desired BMI, while factors like education level or alcohol use did not impact these discrepancies.
Fatty acid amide hydrolase (FAAH) is an enzyme that degrades anandamide, an endocannabinoid that modulates mesolimbic dopamine release and, consequently, influences states of well-being. Despite these known interactions, the specific role of FAAH in subjective well-being remains underexplored. Since well-being is a dynamic trait that can fluctuate over time, we hypothesized that we could provide deeper insights into the link between FAAH and well-being using longitudinal data.
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