Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water.

A novel molecularly imprinted polymer (MIP) against gatifloxacin based on a hybrid monomer (3-triethoxysilylpropyl methacrylic amide, APTES-MAA) was reported. In this study, the imprinted monolith was synthesized with gatifloxacin as template, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and APTES-MAA as functional monomer in a mixture of acetonitrile and isooctane as porogen via an optimization based on density functional theory (DFT). The polymers were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and mercury porosimetry.

Integration of Circulating Tumor DNA and Metabolic Parameters on F-Fludeoxyglucose Positron Emission Tomography for Outcome Prediction in Unresectable Locally Advanced Non-Small Cell Lung Cancer.

This prospective study explores the prognostic value of circulating tumor DNA (ctDNA) and positron emission tomography/computed tomograpy (PET/CT) in unresectable locally advanced non-small cell lung cancer (LA-NSCLC) treated with definitive chemoradiotherapy (CRT). The discovery set includes 62 patients, with 62 baseline and 53 post-CRT plasma samples. PET/CT is performed at baseline, and 33 patients undergo mid-treatment scans after 40 Gy.

Comparison of remimazolam tosylate and propofol in hemodynamic stability, postoperative cognitive function, and recovery in general anesthesia combined with regional nerve blocks: a retrospective cohort study.

Background: General anesthesia (GA) combined with regional anesthesia (RA) is commonly used to enhance perioperative analgesia and hemodynamic stability. This study aimed to compare the hemodynamic effects and postoperative cognitive function between remimazolam tosylate and propofol in patients undergoing GA combined with RA.

Methods: A retrospective cohort study was conducted on 4408 patients who underwent elective upper or lower limb surgeries at our institution from January 2020 to June 2024.

Lung Cancer Biomarker Database (LCBD): a comprehensive and curated repository of lung cancer biomarkers.

Background: Lung cancer remains a leading cause of cancer-related mortality, primarily because of the lack of effective diagnostic and therapeutic biomarkers. To address the issue of fragmented biomarker data across numerous publications, we have developed the Lung Cancer Biomarker Database (LCBD, http://lcbd.biomarkerdb.

A greening Earth has reversed the trend of decreasing carbonate weathering under a warming climate.

The response of mineral weathering and its related Weathering Sink for atmospheric CO (WS) to global vegetation greening are not well understood. After applying different biogeochemical models and a field experiment to investigate the influence of vegetation greening and warming on the variations of carbonate weathering and WS on regional and global scales, here we show a significant positive relationship between global carbonate weathering intensity ([HCO] as a proxy) and vegetation greenness. During 1982-2018, under a warming climate, [HCO] and WS increase by 5.