Publications by authors named "Y F Ramos"
The Mallorquín Swamp, an important ecosystem in Atlántico, Colombian Caribbean, underwent environmental monitoring at eight points during rainy, transition, and dry seasons. This was to assess water quality, seasonal variation, and the bioaccumulation of metals, emerging pollutants, and organic compounds in the fish and . Water parameters were analyzed using descriptive statistics and multifactorial ANOVA with the Tukey HSD test for seasonal differences.
View Article and Find Full Text PDFDengue virus (DENV) causes the most prevalent and rapidly spreading arboviral disease of humans. It enters human cells by receptor-mediated endocytosis. Numerous cell-surface proteins were proposed as DENV entry factors.
View Article and Find Full Text PDFMounting effective immunity against pathogens and tumours relies on the successful metabolic programming of T cells by extracellular fatty acids. Fatty-acid-binding protein 5 (FABP5) has a key role in this process by coordinating the efficient import and trafficking of lipids that fuel mitochondrial respiration to sustain the bioenergetic requirements of protective CD8 T cells. However, the mechanisms that govern this immunometabolic axis remain unexplored.
View Article and Find Full Text PDFArticle Synopsis
- The development of human induced pluripotent stem cell (iPSC)-based therapies is hindered by the absence of specific markers to identify differentiated cell types, particularly notochordal-like cells and chondrocytes, which are essential for treating back pain and osteoarthritis.
- Researchers created two iPSC lines featuring an ACAN-2A-mScarlet reporter to help isolate and study these important cells, bypassing the need for specific markers.
- The versatility of ACAN as a marker for various tissues emphasizes its potential for enhancing research in developmental biology and regenerative medicine.
Background: Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology toward regenerative solutions in the clinical setting. Here, we set out to generate methylome-wide landscapes of hiPSC-derived neo-cartilages from different tissues-of-origin and integrated transcriptome-wide data to identify dissimilarities in set points of methylation with associated transcription and the respective pathways in which these genes act.
Methods: We applied in vitro chondrogenesis using hiPSCs generated from two different tissue sources: skin fibroblasts and articular cartilage.