Single-Atom Cu Anchored on Carbon Nitride as a Bifunctional Glucose Oxidase and Peroxidase Nanozyme for Antibacterial Therapy.

A very promising strategy to avoid bacterial drug resistance is to replace antibiotics with artificial nanozymes, but this has not yet been translated to the clinic. Here, we construct a single-atom nanozyme using graphitic carbon nitride nanosheets modified by copper (Cu--CN). This Cu--CN nanosheet possesses both glucose oxidase-like and peroxidase-like activities responsible for reactive-oxygen-species generation by a cascade reaction to eradicate Gram-positive and Gram-negative multidrug-resistant bacteria.

A 300-km fully-connected quantum secure direct communication network.

Transmission distance and number of users limit the realization of large-scale scalable quantum communication networks, as existing quantum network construction techniques struggle to address these two important factors simultaneously. In this paper, we propose a long-distance large-scale and scalable fully-connected quantum secure direct communication (QSDC) network, which employs a double-pumped structure and the introduction of extra noise to successfully realize QSDC over 300 km between four users in the network in pairs. The results demonstrate that the fidelity of the entangled state shared between users following communication remains above 85%.

Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.

Background And Aims: Antioxidants, including vitamin E (VE) and grape seed extract (GSE), as anti-aging supplementation have been widely used to improve human health. The gut microbiota plays a crucial role in health and affects the treatment effect of various interventions. However, the role of gut microbiota in VE remains unclear.

A comparative study of human norovirus and human sapovirus contamination in oysters (Crassostrea gigas) tissues from physical markets and e-commerce platforms in Guangzhou, China.

Human norovirus (HuNoV) and human sapovirus (HuSaV) are the common foodborne viruses that can be transmitted through the consumption of contaminated shellfish. With the rise of e-commerce, these platforms have become an important channel for Chinese consumers to purchase seafood products. However, the potential impact of this new commercial model on viral contamination necessitates further investigation.

Facile synthesis of 2-MCE capped silver shell optimized core-shell nanosensor for simultaneous detection of insecticide residues in fruit samples.

Surface-enhanced Raman scattering (SERS) is an emerging swift and nondestructive detecting method, offering a unique structural signature of analytes down to ultrasensitive levels. Herein, we present a novel SERS-based core-shell nanostructure with optimized silver shell thicknesses, capped with 2-mercaptoethylamine (2-MCE), to simultaneously detect multiple agrochemical residues in fruit samples. Compared to unmodified Au@AgNPs, the modified Au@Ag@2-MCENPs integrated with SERS exhibited improved sensitivity and stability, exhibiting a strong relationship between the SERS intensities and pesticide concentrations in the fruit samples, with LODs of 0.