Environmental pollution is a significant contributor to male infertility. Numerous environmental pollutants, such as PCB118, act as exogenous ligands for the aryl hydrocarbon receptor (AhR). However, the role of AhR in mediating the effects of environmental pollutants on male reproductive functions remains inadequately understood.
View Article and Find Full Text PDFPseudorabies virus (PRV) is a significant pathogen impacting swine health and poses high zoonotic risks to humans. Effective antiviral treatments for PRV remain limited, underscoring the need for novel therapeutic strategies. In this study, ciprofloxacin was identified as a repurposed promising candidate with significant in vitro inhibition of PRV replication based on our inference from PNU-183792, an HSV-1 DNA polymerase inhibitor, that quinolones have the potential to act as anti-PRV drugs.
View Article and Find Full Text PDFThe diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.
View Article and Find Full Text PDFAn efficient Rh(III)-catalyzed annulation between 3-aryl-2-benzo[][1,4]oxazines and α-diazo-β-ketoesters was developed, affording a series of polycyclic heteroarenes in moderate to excellent yields with good functional group compatibility. The procedure featured high efficiency, redox neutrality, twofold -C-H activation, and dual [4 + 2] annulation. Moreover, several important intermediates and products have been isolated as powerful evidence for the proposed reaction mechanism.
View Article and Find Full Text PDFPerovskite quantum dots (QDs) show an excellent application perspective in semiconductor optoelectronic devices. However, problems of ligand loss during the growth, purification, film formation, and storage process always induce the aggregation and ripening of QDs, adversely affecting QDs' and QD-based devices' performance. Here, we use a bidentate molecule to control ripening toward a notable performance boost in CsPbI QDs.
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