Publications by authors named "Y Eura"
Article Synopsis
- Acquired von Willebrand syndrome (AVWS) is linked to cardiovascular diseases like mitral regurgitation (MR), leading to a decrease in large von Willebrand factor (VWF) multimers, but its specifics with MR are still not fully understood.
- A study analyzed 84 patients with moderate to severe MR, finding that 69% exhibited a significant loss of VWF large multimers, especially in degenerative MR cases, but levels improved after mitral valve intervention.
- The findings indicate that while MR is commonly associated with loss of VWF large multimers, the overall risk of gastrointestinal bleeding remains low, and hemoglobin levels tend to stay stable post-treatment.
Article Synopsis
- Severe aortic stenosis (AS) can lead to acquired von Willebrand syndrome by breaking down important blood clotting factors, requiring accurate diagnosis methods to identify the condition.* -
- The study evaluated the effectiveness of the VWF Ristocetin co-factor activity to antigen levels (VWF:RCo/VWF:Ag) ratio as a diagnostic tool for AS-induced von Willebrand syndrome using data from 382 AS patients and controls.* -
- Results showed a VWF:RCo/VWF:Ag ratio of <0.7 is specific for detecting loss of important blood clotting multimers in patients with AS, but it has low sensitivity, indicating it might miss some cases.*
Background: The plasma metalloprotease ADAMTS13 regulates the thrombotic activity of the von Willebrand factor (VWF). ADAMTS13 is highly glycosylated and its carbohydrate chains are capped with sialic acid (SA). Thus, ADAMTS13 may interact with carbohydrate- and/or SA-binding plasma membrane receptors that are involved in the clearance of various plasma proteins.
View Article and Find Full Text PDFMembrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear. The hemostatic protein von Willebrand factor is produced in vascular endothelial cells and packaged into specialized secretory granules, Weibel-Palade bodies (WPBs) at the -Golgi network (TGN). Here, we reported that V0a1, a V-ATPase component, is required for the membrane fission of WPBs.
View Article and Find Full Text PDFVon Willebrand factor (VWF) is a 500- to 15 000-kDa multimeric protein circulating in the blood. When VWF has a higher molecular weight, its hemostatic activity is greater. The size distribution of VWF multimers is usually analyzed by SDS-agarose gel electrophoresis followed by immunoblotting.
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