Transcarotid retrograde stenting for common carotid artery ostial stenosis: how I do it.

Background: We present a surgical technique for retrograde stenting of ostial stenosis of the common carotid artery (CCA) in a 74-year-old male patient.

Method: The carotid bifurcation was widely exposed. A 9-French (Fr) balloon guide catheter (BGC) was inserted via a small arteriotomy of the CCA and fixed using balloon inflation.

Antiplatelet Therapy in Endovascular Treatment of Cerebral Aneurysms.

Thromboembolism is one of the main causes of severe complications in the endovascular treatment of cerebral aneurysms, and antiplatelet therapy (APT) is necessary to prevent such complications. Conversely, prolonged APT has the potential risk of hemorrhagic complications; therefore, the timing of dose reduction or discontinuation is an important aspect of periprocedural APT. However, no clinical evidence of an optimal regimen of APT for cerebral aneurysms exists, and the selection, dosage, duration, or combination of antiplatelets has been dependent on physicians for unruptured or ruptured cerebral aneurysms.

Two distinct phenotypes in Snijders Blok-Campeau syndrome and characterization of the behavioral phenotype in a zebrafish model.

Chromatin remodeling is an important system controlling gene expression. CHD3, which is a causative gene of Snijders Blok-Campeau syndrome (SNIBCPS), is a member of the chromodomain helicase DNA-binding (CHD) family related to chromatin remodeling. SNIBCPS is characterized by developmental delay (DD), intellectual disability (ID), macrocephaly, and facial features including a prominent forehead and hypertelorism.

Arduous management in treatment of elderly patient with pulmonary arterial hypertension and cardiopulmonary comorbidities.

Elderly patients with pulmonary arterial hypertension (PAH) exhibit distinct features and outcomes compared to classical patients. Cardiopulmonary comorbidities are common and likely contribute to the development of pulmonary hypertension (PH). However, solid evidence for treating elderly PAH patients with these comorbidities remains lacking, complicating management.