Publications by authors named "Y Elkabetz"
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to provide improved resolution of early regulatory dynamics, including detailed molecular definitions of most cell states during mouse embryogenesis. Here we used Slide-seq to build spatial transcriptomic maps of complete embryonic day (E) 8.
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- Cerebral organoids show varied regions but have limited cellular diversity, hinting at poor early neural stem cell (NSC) patterning.
- A short early treatment using Dual SMAD and WNT inhibition can effectively establish a stable cortical NSC identity and minimize non-cortical cell types.
- This method enhances the appearance of crucial neuron types and helps reveal specific defects, making it essential for accurately modeling cortical development and related diseases.
Recently in Science Translational Medicine, Bagó et al. (2017) reported an advance in treating glioblastoma using tumor-homing cytotoxic induced neural stem cells (h-iNSC). This approach circumvents problems associated with immune rejection and minimizes the bench-to-clinic time window critical for these patients.
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