Atypical Antiadrenergic Effect of Refralon as a Mechanism of High Antiarrhythmic Effectiveness.

We studied the effect of Refralon on the electrophysiological properties of the supraventricular myocardium against the background of adrenergic (epinephrine) influence in the zone of the pulmonary veins, the area where 50-90% of atrial arrhythmias is triggered. The experiments were carried out on isolated tissue preparations of Wistar rats. The multichannel microelectrode array technique was used to record action potentials simultaneously in the atrium and in the ostium and distal parts of the pulmonary veins.

Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium.

A number of pharmacological drugs have side effects that contribute to the occurrence of atrial fibrillation, the most common type of cardiac rhythm disorders. The clinical use of antihistamines is widespread; however, information regarding their anti- and/or proarrhythmic effects is contradictory. In this work, we studied the effects and mechanisms of the potential proarrhythmic action of the first-generation antihistamine chloropyramine (Suprastin) in the atrial myocardium and pulmonary vein (PV) myocardial tissue.

Polarization structure of optical vortices in inclined Laguerre-Gaussian beams passed through a uniaxial crystal.

The work shows that in linearly polarized Laguerre-Gaussian beams passing through an anisotropic medium at an angle to the optical axis of the crystal, the distribution of optical vortices is devoid of axial symmetry. It is shown that the trajectories of movement of polarization singularities in the plane of the Laguerre-Gauss beam are different for different cases of input linear polarization at angles =±45 and there is an exchange of optical vortices, provided that the sign of the topological charge is preserved. It is shown that when the axis of an anisotropic medium is tilted, the movement of optical vortices occurs, accompanied by topological reactions of creation, destruction, or displacement of optical vortices to the periphery of the beam.

Pulsatile Features of Major Arteries in Rats during Hypotension Caused by Acute Blood Loss.

The study examined the modes of pulsations of the femoral and carotid arteries of rats in situ (n=14) during acute blood loss, which sequentially caused a deep BP drop, cardiac and respiration arrest, and termination of ECG signals. When BP dropped to 19 (13; 26) mm Hg, the mechanosensitivity of passively pulsing arteries determined by the ratio of the swing range of electroimpedance oscillations of arterial segment to pulse pressure increased by 3.2 (2 ; 4) times (p<0.

Fast oscillations of orbital angular momentum and Shannon entropy caused by radial numbers of structured vortex beams.

We address theoretical and experimental considerations of two-parameter excitation of each Hermite-Gaussian (HG) mode in composition of a structured Laguerre-Gaussian (sLG) beam. The complex amplitude of the sLG beam is shaped in such a way that the radial and azimuthal numbers of eigenmodes are entangled with each other. As a result, variations in the amplitude and phase parameters of mode excitation, although dramatically changing the intensity and phase patterns, do not change the structural stability of the beam.