Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A.

Immunoglobulin A (IgA) is secreted into breast milk and is critical for both protecting against enteric pathogens and shaping the infant intestinal microbiota. The efficacy of breast milk-derived maternal IgA (BrmIgA) is dependent upon its specificity; however, heterogeneity in BrmIgA binding ability to the infant microbiota is not known. Using a flow cytometric array, we analyzed the reactivity of BrmIgA against bacteria common to the infant microbiota and discovered substantial heterogeneity between all donors, independent of preterm or term delivery.

Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A.

Unlabelled: Immunoglobulin A (IgA) is secreted into breast milk and is critical to both protecting against enteric pathogens and shaping the infant intestinal microbiota. The efficacy of breast milk-derived maternal IgA (BrmIgA) is dependent upon its specificity, however heterogeneity in BrmIgA binding ability to the infant microbiota is not known. Using a flow cytometric array, we analyzed the reactivity of BrmIgA against bacteria common to the infant microbiota and discovered substantial heterogeneity between all donors, independent of preterm or term delivery.

Hematologic malignancies of the breast: report of three cases.

Involvement of the breast by hematologic malignancies is rare and remains an important diagnostic challenge for radiologists. We present the cases of 3 patients diagnosed with hematologic breast malignancies at our institutions. All cases were diagnosed by breast core biopsies, which revealed 2 cases of diffuse B-cell lymphoma and one case of myeloid sarcoma associated with acute myeloblastic leukemia (AML).

Impact of Field Isolate Identified Nonsynonymous Single Nucleotide Polymorphisms on Equilibrative Nucleoside Transporter 1 Inhibitor Efficacy.

causes the most severe form of malaria and causes approximately 500 000 deaths per year. . parasites resistant to current antimalarial treatments are spreading.

Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Parasite Proliferation.

Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the equilibrative nucleoside transporter type 1 (PfENT1). We previously showed that PfENT1 inhibitors block parasite proliferation in culture.