Publications by authors named "Y E Komarov"
Article Synopsis
- - Lung cancer rates in Russia, particularly among men, have declined since the 1990s due to reduced smoking, but recent trends show rising incidence rates, especially in women since 2012, while mortality rates remain stable.
- - The study utilized national cancer reports and the Russian Fertility and Mortality Database from 1965-2021 to analyze changes in lung cancer incidence and mortality, revealing significant shifts starting around 2013 for men and 2012 for women.
- - An increase in the use of CT scans coincides with these trends, suggesting the need for ongoing monitoring to assess the impact of improved diagnostic methods on lung cancer outcomes in Russia.
Background: A national framework for population-based cancer registration was established in Russia in the late 1990s. Data comparability and validity analyses found substantial differences across ten population-based cancer registries (PBCRs)in Northwest Russia, and only four out of ten met international standards. This study aimed to assess the completeness of the PBCR data of those registries.
View Article and Find Full Text PDFBackground: Despite the elaborate history of statistical reporting in the USSR, Russia established modern population-based cancer registries (PBCR) only in the 1990s. The quality of PBCRs data has not been thoroughly analyzed. This study aims at assessing the comparability and validity of cancer statistics in regions of the Northwestern Federal District (NWFD) of Russia.
View Article and Find Full Text PDFOver the past five years drug therapy of disseminated melanoma took a giant step forward. In clinical practice there are several fundamentally new classes of drugs: inhibitors of the individual components of MAPK-signaling pathway and modulators of a work of immunological synapse (inhibitor of CTLA4 ipilimumab, inhibitors of PD1 nivolyumab and pem- brolizumab).Here are presented features of the mechanism of action of new immunotherapeutic agents, the review of results of their clinical use, the description of the main treatment- related adverse events.
View Article and Find Full Text PDFThis work presents results of long-term phase-contrast microscopy research of proliferative potential of soft tissue sarcomas utilizing live-cell imaging technology Cell-IQ (Chip-Man Technologies Ltd, Finland). It was found that the machine vision technology allowed to obtained sufficient body of evidence about high-quality and quantitative changes of proliferative activity of the cells soft tissue sarcoma cultivated in static conditions. The present study demonstrates that modeling in time interval of maximum proliferative activity of soft tissue sarcoma cells increases information efficacy and reliability of the analysis of dividing cells patterns using Cell-IQ technology.
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